I'd like to see a new version of the Buffy The Vampire Slayer RPG. Of course, Eden Studios lost the licence, so it won't happen with Unisystem, but maybe if someone else got the rights to it they could make a new one.
I'm thinking either a Cortex or Fate-based version would work. One of my first thoughts after buying the Dresden Files RPG was that I could maybe adapt it to run a Buffy campaign. And Margaret Weiss have been doing some good licenced stuff lately, so they could probably pull something off.